PC-TraFF server is a complete
web tool that aims to identify potentially collaborating
transcription factors (TFs) based on the locations of
their binding sites in sequences. The
binding of TFs frequently occurs in a cooperative manner due to
their potential functional collaboration which leads to as cis-regulatory modules (CRMs). These modules are important for
an effective regulation of the transcriptional machinery, even
if they are not enriched in the corresponding promoter regions.
The collaboration of TFs might stem from synergistic or
antagonistic interactions between homotypic as well as
heterotypic TFs. Such collaborations are likely to have effect
on gene specificity and flexibility of the controlling of gene
transcription ([PMID:18406148], [PMID:15930495], [PMID:22369666]).
We would highly recommend to use of professional version of PC-TraFF server: